![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g001.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Frontiers | Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective Frontiers | Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective](https://www.frontiersin.org/files/Articles/551365/fphar-11-01078-HTML/image_m/fphar-11-01078-g001.jpg)
Frontiers | Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective
![Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons | eLife Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons | eLife](https://iiif.elifesciences.org/lax/69746%2Felife-69746-fig7-v3.tif/full/full/0/default.jpg)
Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons | eLife
![Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor: Trends in Pharmacological Sciences Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor: Trends in Pharmacological Sciences](https://www.cell.com/cms/attachment/763e3174-aa34-42c8-9d54-6c4b4c4be691/gr1_lrg.jpg)
Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor: Trends in Pharmacological Sciences
![Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP‐dependent manner - Santhappan - 2015 - Journal of Neurochemistry - Wiley Online Library Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP‐dependent manner - Santhappan - 2015 - Journal of Neurochemistry - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/c532538f-7e3e-4302-be5c-f6697d4c71f8/jnc13222-fig-0007-m.jpg)
Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP‐dependent manner - Santhappan - 2015 - Journal of Neurochemistry - Wiley Online Library
![Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling | Science Signaling Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling | Science Signaling](https://www.science.org/cms/10.1126/scisignal.aac9177/asset/a1cae515-9003-4618-a9bc-2a67c937a4a1/assets/graphic/9_ra16_f7.jpeg)
Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling | Science Signaling
![Regulation of opioid receptor signalling: Implications for the development of analgesic tolerance | Molecular Brain | Full Text Regulation of opioid receptor signalling: Implications for the development of analgesic tolerance | Molecular Brain | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2F1756-6606-4-25/MediaObjects/13041_2011_Article_125_Fig1_HTML.jpg)
Regulation of opioid receptor signalling: Implications for the development of analgesic tolerance | Molecular Brain | Full Text
![Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias - ScienceDirect Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0898656820303831-gr1.jpg)
Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias - ScienceDirect
![Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives | SpringerLink Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00535-013-0753-x/MediaObjects/535_2013_753_Fig2_HTML.gif)
Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives | SpringerLink
![Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA) Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)](https://nida.nih.gov/sites/default/files/styles/content_image_medium/public/images/valenza_zamarripa_promo.jpg?itok=HRbtRBEw)
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)
![Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics](https://jpet.aspetjournals.org/content/jpet/338/1/92/F9.large.jpg)
Regulation of κ-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo | Journal of Pharmacology and Experimental Therapeutics
![Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/acschemneuro.9b00195/asset/images/medium/cn-2019-00195v_0008.gif)
Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience
![Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41598-021-88118-6/MediaObjects/41598_2021_88118_Fig7_HTML.png)